{"id":1176,"date":"2019-06-18T18:15:53","date_gmt":"2019-06-18T10:15:53","guid":{"rendered":"http:\/\/www.bioactivescreeninglibrary.com\/?p=1176"},"modified":"2022-01-07T10:53:32","modified_gmt":"2022-01-07T02:53:32","slug":"chemopreventive-effect-resv-increased-breast-cancer-incidence-observed-study","status":"publish","type":"post","link":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/2019\/06\/18\/chemopreventive-effect-resv-increased-breast-cancer-incidence-observed-study\/","title":{"rendered":"A chemopreventive effect of Resv whereas increased breast cancer incidence is observed in one study"},"content":{"rendered":"

The reason for these contradictory results is not obvious. Resveratrol reduced chemically-induced liver cancer in rats and in mice 4-(Benzyloxy)phenol<\/a> injected with carcinoma cells. A single Catharanthine sulfate<\/a> experiment showed no reduction of the incidence of esophagus carcinoma formation by Resv. The effect of Resv on gastric cancers was evaluated with its effect on tumor growth after subcutaneous injection of cancer cells. Both studies in mice showed a reduced tumor volume as a consequence of Resv exposure. To study the effect of Resv on colon cancer development in animals, four studies focus on chemically-induced colon cancer in rats or mice and three studies evaluated the effect of Resv on colon cancer in APC\/Min mice strains. Three of the tests showed significant reduction of the aberrant crypt formation or incidence of adenomas, whereas two of the mouse studies did not show a significant reduction in colon cancer incidence or tumor load. Resveratrol showed a chemopreventive effect on development of prostate cancer using rat or mice strains prone to spontaneously developing prostate cancer and a mouse model with injected prostate cancer cells In other studies focusing on lung carcinogenesis, Resv showed a chemopreventive effect only in a single experiment out of a total of four experiments. A single study focused on the effect of Resv on the development of neuroblastoma in mice, and found reduced tumor volume. Several animal studies have indicated that Resv has a neuroprotective effect. In total, 12 studies test the effect of resveratrol after a single exposure and 28 studies investigated the effect of resveratrol af subchronic\/chronic exposure. This effect of Resv has been documented in various animal models including rabbits, mice or rats and using different end points, such as reduced lipid peroxidation and neurological cell destruction, attenuation of induced lesion areas, induced tolerance to brain injury, reduced frequency of seizures, impairment of motor coordination and enhancement of learning. Only very few of these experiments found no or a marginal effect of Resv. Inflammatory response is a well known mechanism of the diseases described above such as cancer, coronary-heart disease, diabetes and neurodegeneration. Resveratrol is shown to modulate the inflammatory response induced by various stimuli. Fourteen studies have investigated the effect of exposure of one week or more to Resv on various inflammatory markers in rats. The same number of studies has been identified using mice as an experimental model. Generally, Resv in nearly all models counteracted the increased levels of pro inflammatory biochemical markers, such as TNFa, IL-1b, IL-6 in nearly all models. Beside these cytokines, MCP-1, COX-2 and iNOS was most often found to be downregulated by Resv when stimulated by the pro-inflammatory treatment. The estimates of inflammation were often performed as a part of a study with another aim, i.e. testing a chemopreventive effect, or the effect of Resv on diabetes or cardiovascular disease. Therefore, different inducers of the inflammatory status have been used; Resv reduced inflammation in several models such as obesityinduced, in diabetic mice or chemically induced diabetes, but also dextran sulfate sodium induced colon colitis. Other models were using induced hypertension, chemicals causing tissue injury in liver, lung and colon and showed decreased levels of inflammatory markers. Besides the animal experiments described above which focused on chronic or near-chronic exposures, a long list of papers exist that analyze the effect of Resv after an acute exposure on biomarkers relevant for prevention.<\/p>\n","protected":false},"excerpt":{"rendered":"

The reason for these contradictory results is not obvious. Resveratrol reduced chemically-induced liver cancer in rats and in mice 4-(Benzyloxy)phenol injected with carcinoma cells. A single Catharanthine sulfate experiment showed no reduction of the incidence of esophagus carcinoma formation by Resv. The effect of Resv on gastric cancers was evaluated with its effect on tumor … Continue reading “A chemopreventive effect of Resv whereas increased breast cancer incidence is observed in one study”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/posts\/1176"}],"collection":[{"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/comments?post=1176"}],"version-history":[{"count":1,"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/posts\/1176\/revisions"}],"predecessor-version":[{"id":1177,"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/posts\/1176\/revisions\/1177"}],"wp:attachment":[{"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/media?parent=1176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/categories?post=1176"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.bioactivescreeninglibrary.com\/index.php\/wp-json\/wp\/v2\/tags?post=1176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}