We are aware of this possible interpretation of results which seems however unlikely given that a number of corticosteroids, ACTH, or IL1-RA exerted the same effects. While our results cannot fully confirm or rule out a specific neuronal action of steroids the fact that the response spanned across a wide range of anti-inflammatory molecules makes this unlikely. Finally, while steroidal treatment showed promise in our study, the fact remains that the use of potent and potentially harmful anti-inflammatory drugs is not a viable long-term option. The treatment, when successful, had to be repeated once the efficacy waned. This is likely due to traditional, concurrent etiologic mechanisms including cortical dysplasia, other brain lesions, etc. The proposed scenario thus implies that: 1) reduced BBB function on an abnormal cortical/hippocampal background facilitates seizures; 2) The lesional tissue itself promotes BBB dysfunction, cooperating towards a further decrease of the threshold for seizures; 3) Steroids ����repair���� the BBB while having no impact on circuital and structural abnormalities. This reduces seizure probability; 4) The anti-inflammatory efficacy decreases over time. This vicious cycle, to be interrupted requires simultaneous targeting of neurons and endothelial cells. In multiple drug resistant patients, AEDs are obviously not sufficient to reduce hypersynchronous firing: a new therapy combing anti-inflammatory potency with neuronal targeting may be the 3-Methoxytyramine hydrochloride necessary and winning combination. Food waste, usually from residential, commercial establishments, institutional and industrial sources, is generated at an ever-increasing rate with the rapid population growth and rising living standards in China. It seems to be a good idea to reuse this favorable feedstock for energy recovery and municipal solid waste reduction because FW Levocabastine hydrochloride contains high moisture and biodegradable organics and accounts for 40�C50% of the weight of MSW. Anaerobic digestion is the most attractive and cost-effective technology for treating sorted organic fraction of MSW, especially food wastes. Various AD processes have been widely developed in many countries for the treatment of FW. So far, three main types of AD technologies have been developed according to the total solids content of feedstocks: conventional wet, semi-dry and modern dry processes.