The RTK mediated tyrosine phosphor-proteome network under insulin and EGF RTKs has not only validated existing tyrosine phosphorylated signaling nodes but also reveals several novel insights in to regulation of RTK signaling and crosstalk with various other pathways. The novel tyrosine phosphorylation events from the Drosophila proteome conserved in 100 human orthologs and paralogs constitute a valuable resource to translate the missing signaling connections and nodal points in the human proteome from the perspective of disease development. The data warrants further validation in human tumor cell lines and tissue samples to see if these pY events are up-regulated or down-regulated in GF signaling with respect to human disease phenotypes. Recent reports indicate the importance of genes in glycolytic pathways in cancer progression. Mechanisms of tumor growth based on the selective switching of cellular processes towards anabolic pathways rather than oxidative phosphorylation also stress the importance of glycolytic proteins in cancer development. Our study in the fly proteome reveals that several proteins involved in glycolytic pathways are tyrosine phosphorylated and that these candidate human proteins with conserved tyrosine residues merit further study. Upregulation of monocarboxylic transporters in Type-1 diabetic patients indicate the possibility of increased capacity of the brain to use non-glucose substrates to meet energy requirements during hypoglycemia. Our study reveals that several MCA transporters are tyrosine phosphorylated upon RTK activation. It will be interesting to see if the human orthologs with conserved phosphorylated tyrosines found in this study are involved in similar mechanisms in brain-cell energetics. Based on the available protein expression data, interesting candidate proteins could be selected for analysis of the dynamics of tyrosine phosphorylation with respect to disease development. Reverse-phase protein microarrays could be a very useful tool in this direction.Major depressive disorder is a debilitating neuropsychiatric disease with high prevalence in the Western World population. It is characterized by changes in behavior including e.g. anhedonia, anxiety, despair or hopelessness, decreased activities of daily living, poor concentration and decreased learning and memory abilities, as previously reviewed.