Azathioprine LOC409705 is responsible for imaginal disc-derived wing morphogenesis. These proteins were significantly down-regulated, probably directly impacting the larval development. As indicated in Figure 1, the Ac Cefathiamidine larvae fed with RJC were not resistant to CSBV infection. Although the up-and down-regulated protein expressions were detected from those bee larvae, it seemed that these proteins were not actively involved in effectively protecting the larvae from CSBV infection. Whether some Ac expressed proteins were active for helping viral infection needs further study. Eukaryotic translation initiation factor 5a plays an important role in protein translation extending, and in stress tolerance. Triosephosphate isomerase is a glycolytic enzyme. Act88F is involved in phagocytosis. HSP 60 and yellow-e2 are both activated by environmental factors as discussed above. They were downregulated may indicated that the influence of CSBV were weakened when the Ac larvae fed with RJM. Among the up-regulated proteins, those involved in energy metabolism were the majority, including PDI, FBA, ALD, PGK and GAPDH. This was in according with the expression pattern of Ac larvae fed with RJM. 26S proteasome plays a fundamental role in eukaryotic homeostasis. The ubiquitin-proteasome system mediated viral protein degradation constitutes a host defense process against some RNA viral infections. In the present study Rpn9 and HSPs were both up-regulated, indicating the possible involvement of these proteins in antiviral activity. Correspondingly, chaperonins or store proteins were down-regulated. This may guarantee the normal growth of Am larvae. As a source of amino acids for tissue reconstruction during pupal development, hexamerins are first synthesized by a larval fat body and released into the hemolymph where they accumulate to extraordinarily high concentrations to build adult structures.Pericentric heterochromatin is a well studied example of a stable condensed chromatin structure that can be inherited from one cell to its daughters, and provides a model system of epigenetic inheritance of a chromatin state.