High intraocular pressure is considered a major risk factor for glaucomatous neuropathies. IOP level is partly regulated by the rate of aqueous humor formation, which normally equals the rate of outflow. Abnormalities in AH turnover have been implicated in most types of hypertensive glaucoma. However, a progressive loss of vision can occur in patients with normal tension as well as when their IOP is controlled with drugs, and oxidative stress is now well known to play a critical role in RGC degeneration. This role has been suggested by the decrease in systemic glutathione levels in patients with primary open-angle glaucoma and the association of this form of glaucoma with a polymorphism of the glutathione S-transferase gene. The importance of combating oxidative stress to ensure RGC survival was confirmed by the prevention of RGC degeneration by taurine, a major antioxidant. The dog, an animal of intermediate size with an ocular anatomy and physiology similar to that of humans and living in the same environment as humans, may constitute a suitable model for the investigation of susceptibilities to glaucoma because spontaneous glaucomas are observed in certain dog breeds. As in humans, the primary risk factor for glaucoma in dogs seems to be high IOP, also regulated by AH turnover. AH drainage mechanisms involve the Silmitasertib iridocorneal angle and the anterior opening of the ciliary cleft, which are spanned by the comb-like pectinate ligament. The passage of AH between the intraligamentary spaces leads to its entry into the uveal and then the corneoscleral trabecular meshwork before being collected by the angular aqueous plexus, the intrascleral plexus, and the vortex venous drainage system. Drainage via this conventional route accounts for 85% of AH outflow in dogs. Pectinate ligament abnormalities, involving a lack of resorption of the mesenchymatous tissue filling the anterior part of the ciliary cleft during embryonic development, have often been reported in association with primary narrow and closed-angle glaucoma. Primary glaucomas are further classified as having an open or narrow ICA on the basis of either gonioscopic examination or imaging by ultrasound biomicroscopy. The underlying genetic susceptibilities potentially contributing to the development and progression of primary glaucoma have never been clearly identified. Glaucoma is genetically heterogeneous, and many genes have been reported to be linked to primary open-angle glaucoma in both humans and dogs. In several dog breeds, including the Chow Chow, the Samoyed, and the Keeshound, primary glaucoma is considered to be hereditary with a prevalence of 4.7% and 1.6%, in Chow Chow and Samoyed dogs, respectively. These two breeds were used to generate Eurasier dogs : a breed obtained in the early 1960s by Julius Whipfel in Germany and characterized by a small population size and intense inbreeding.